Issue 1, 2014

Gadolinium oxysulfide nanoparticles as multimodal imaging agents for T2-weighted MR, X-ray tomography and photoluminescence

Abstract

We have synthesized gadolinium oxysulfide nanoparticles (NPs) doped with other lanthanides (Eu3+, Er3+, Yb3+) via a hydroxycarbonate precursor precipitation route followed by a sulfuration process under a H2S–Ar atmosphere at 750 °C in order to propose new multimodal nanoplatforms for Magnetic Resonance (MR), X-ray and photoluminescence imaging. Gd2O2S:Eu3+ NPs strongly absorb near UV (≈300–400 nm) and re-emit strong red light (624 nm). They can be easily internalized by cancer cells, and imaged by epifluorescence microscopy under excitation in the NUV (365 nm). They are not cytotoxic for living cells up to 100 μg mL−1. Consequently, they are well adapted for in vitro imaging on cell cultures. Gd2O2S:Eu3+ NPs also show strong transverse relaxivity and strong X-ray absorption allowing their use as contrast agents for T2-weighted MRI and X-ray tomography. Our study shows that Gd2O2S:Eu3+ NPs are considerably better than commercial Ferumoxtran-10 NPs as negative contrast agents for MRI. Upconversion emission of Gd2O2S:Er; Yb (1; 8%) NPs under infrared excitation (λex = 980 nm) shows mainly red emission (≈650–680 nm). Consequently, they are more specifically designed for in vivo deep fluorescence imaging, because both excitation and emission are located inside the “transparency window” of biological tissues (650–1200 nm). Magnetic relaxivity and X-ray absorption behaviors of Gd2O2S:Er; Yb NPs are almost similar to Gd2O2S:Eu3+ NPs.

Graphical abstract: Gadolinium oxysulfide nanoparticles as multimodal imaging agents for T2-weighted MR, X-ray tomography and photoluminescence

Supplementary files

Article information

Article type
Paper
Submitted
31 Jul 2013
Accepted
18 Oct 2013
First published
24 Oct 2013

Nanoscale, 2014,6, 555-564

Gadolinium oxysulfide nanoparticles as multimodal imaging agents for T2-weighted MR, X-ray tomography and photoluminescence

Sèmiyou. A. Osseni, S. Lechevallier, M. Verelst, P. Perriat, J. Dexpert-Ghys, D. Neumeyer, R. Garcia, F. Mayer, K. Djanashvili, J. A. Peters, E. Magdeleine, H. Gros-Dagnac, P. Celsis and R. Mauricot, Nanoscale, 2014, 6, 555 DOI: 10.1039/C3NR03982J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements