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Issue 22, 2014
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Boron dipyrromethene (BODIPY) functionalized carbon nano-onions for high resolution cellular imaging

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Abstract

Carbon nano-onions (CNOs) are an exciting class of carbon nanomaterials, which have recently demonstrated a facile cell-penetration capability. In the present work, highly fluorescent boron dipyrromethene (BODIPY) dyes were covalently attached to the surface of CNOs. The introduction of this new carbon nanomaterial-based imaging platform, made of CNOs and BODIPY fluorophores, allows for the exploration of synergetic effects between the two building blocks and for the elucidation of its performance in biological applications. The high fluorescence intensity exhibited by the functionalized CNOs translates into an excellent in vitro probe for the high resolution imaging of MCF-7 human breast cancer cells. It was also found that the CNOs, internalized by the cells by endocytosis, localized in the lysosomes and did not show any cytotoxic effects. The presented results highlight CNOs as excellent platforms for biological and biomedical studies due to their low toxicity, efficient cellular uptake and low fluorescence quenching of attached probes.

Graphical abstract: Boron dipyrromethene (BODIPY) functionalized carbon nano-onions for high resolution cellular imaging

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Publication details

The article was received on 07 Aug 2014, accepted on 10 Sep 2014 and first published on 12 Sep 2014


Article type: Paper
DOI: 10.1039/C4NR04533E
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2014,6, 13761-13769
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    Boron dipyrromethene (BODIPY) functionalized carbon nano-onions for high resolution cellular imaging

    J. Bartelmess, E. De Luca, A. Signorelli, M. Baldrighi, M. Becce, R. Brescia, V. Nardone, E. Parisini, L. Echegoyen, P. P. Pompa and S. Giordani, Nanoscale, 2014, 6, 13761
    DOI: 10.1039/C4NR04533E

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