The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation ‘silent’ surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.
The article was received on 21 Jul 2014, accepted on 01 Oct 2014 and first published on 02 Oct 2014
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