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Issue 9, 2014
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Photo-redox activated drug delivery systems operating under two photon excitation in the near-IR

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Abstract

We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by “snap-top” caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes inter-molecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. We describe the operation of the “snap-top” release mechanism by both one- and two-photon activation. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy.

Graphical abstract: Photo-redox activated drug delivery systems operating under two photon excitation in the near-IR

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Publication details

The article was received on 19 Nov 2013, accepted on 17 Feb 2014 and first published on 21 Feb 2014


Article type: Paper
DOI: 10.1039/C3NR06155H
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Citation: Nanoscale, 2014,6, 4652-4658
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    Photo-redox activated drug delivery systems operating under two photon excitation in the near-IR

    T. M. Guardado-Alvarez, L. S. Devi, J. Vabre, T. A. Pecorelli, B. J. Schwartz, J. Durand, O. Mongin, M. Blanchard-Desce and J. I. Zink, Nanoscale, 2014, 6, 4652
    DOI: 10.1039/C3NR06155H

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