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Issue 1, 2014
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Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies

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Abstract

Long-circulating polymeric nanotherapeutics have garnered increasing interest in research and in the clinic owing to their ability to improve the solubility and pharmacokinetics of therapeutic cargoes. Modulation of carrier properties promises more effective drug localization at the disease sites and can lead to enhanced drug safety and efficacy. In the present review, we highlight the current development of polymeric nanotherapeutics in the clinic. In light of the importance of stealth properties in therapeutic nanoparticles, we also review the advances in stealth functionalization strategies and examine the performance of different stealth polymers in the literature. In addition, we discuss the recent development of biologically inspired “self” nanoparticles, which present a differing stealth concept from conventional approaches.

Graphical abstract: Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies

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Publication details

The article was received on 14 Oct 2013, accepted on 29 Oct 2013 and first published on 04 Nov 2013


Article type: Review Article
DOI: 10.1039/C3NR05444F
Citation: Nanoscale, 2014,6, 65-75
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    Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies

    C. J. Hu, R. H. Fang, B. T. Luk and L. Zhang, Nanoscale, 2014, 6, 65
    DOI: 10.1039/C3NR05444F

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