Jump to main content
Jump to site search

Issue 3, 2014
Previous Article Next Article

Topography-controlled alignment of DNA origami nanotubes on nanopatterned surfaces

Author affiliations

Abstract

The controlled positioning of DNA nanostructures on technologically relevant surfaces represents a major goal along the route toward the full-scale integration of DNA-based materials into nanoelectronic and sensor devices. Previous attempts to arrange DNA nanostructures into defined arrays mostly relied on top-down lithographic patterning techniques combined with chemical surface functionalization. Here we combine two bottom-up techniques for nanostructure fabrication, i.e., self-organized nanopattern formation and DNA origami self-assembly, in order to demonstrate the electrostatic self-alignment of DNA nanotubes on topographically patterned silicon surfaces. Self-organized nanoscale ripple patterns with periodicities ranging from 20 nm to 50 nm are fabricated by low-energy ion irradiation and serve as substrates for DNA origami adsorption. Electrostatic interactions with the charged surface oxide during adsorption direct the DNA origami nanotubes to the ripple valleys and align them parallel to the ripples. By optimizing the pattern dimensions and the Debye length of the adsorption buffer, we obtain an alignment yield of ∼70%. Since this novel and versatile approach does not rely on any chemical functionalization of the surface or the DNA nanotubes, it can be applied to virtually any substrate material and any top-down or bottom-up nanopatterning technique. This technique thus may enable the wafer-scale fabrication of ordered arrays of functional DNA-based nanowires.

Graphical abstract: Topography-controlled alignment of DNA origami nanotubes on nanopatterned surfaces

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Aug 2013, accepted on 24 Nov 2013 and first published on 26 Nov 2013


Article type: Paper
DOI: 10.1039/C3NR04627C
Citation: Nanoscale, 2014,6, 1790-1796
  •   Request permissions

    Topography-controlled alignment of DNA origami nanotubes on nanopatterned surfaces

    B. Teshome, S. Facsko and A. Keller, Nanoscale, 2014, 6, 1790
    DOI: 10.1039/C3NR04627C

Search articles by author

Spotlight

Advertisements