Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators

María Jesús Durán-Peña; José Manuel Botubol Ares; Isidro G. Collado; Rosario Hernández-Galán

doi:10.1039/C4NP00008K

Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators

María Jesús Durán-Peña,^a José Manuel Botubol Ares,^a Isidro G. Collado*^a and Rosario Hernández-Galán*^a

* Corresponding authors

^a Department of Organic Chemistry, Faculty of Science, University of Cádiz, Polígono Río San Pedro s/n, Spain
E-mail: isidro.gonzalez@uca.es, rosario.hernandez@uca.es

Abstract

Covering: 1973 to 2013

The biological activities of tigliane, lathyrane, ingenane, casbane, jatropholane and premyrsinane diterpenoids which contain the gem-dimethylcyclopropyl unit are described. Particular attention is given to their anti-viral, anti-microbial and cytotoxic activities. In the main text there are 132 references. The electronic supplementary information contains tables listing 424 of these diterpenoids, their occurrence and biological activity together with the references.

Graphical abstract: Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators

Supplementary files

Publication details

The article was received on 22 Jan 2014 and first published on 21 May 2014

Article type: Review Article

DOI: 10.1039/C4NP00008K

Author version available: Download Author version (PDF)

Citation: Nat. Prod. Rep., 2014,31, 940-952

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Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators

M. J. Durán-Peña, J. M. Botubol Ares, I. G. Collado and R. Hernández-Galán, Nat. Prod. Rep., 2014, 31, 940
DOI: 10.1039/C4NP00008K
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Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators

Abstract

Supplementary files

Publication details

Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators

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