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Issue 6, 2014
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Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells

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Abstract

The structure–activity relationships of the natural flavonoids quercetin, chrysin and silibinin have revealed that they meet the key structural requirements for killing tumor cells. When the structures of these three flavonoids are modified by complexation using the oxovanadium(IV) cation their cytotoxic properties in human breast cancer cell lines are enhanced. Breast epithelial cells are used to determine the selectivity of these compounds. The mechanisms of action of the flavonoids and the oxovanadium(IV) cation in the MDA-MB231 cell line seem to be different to the apoptotic mechanisms of cell death exerted by the oxovanadium(IV) complexes. These results showed the mechanisms of the antitumoral effect of these complexes, making them promising compounds for cancer treatment.

Graphical abstract: Specific antitumor activities of natural and oxovanadium(iv) complexed flavonoids in human breast cancer cells

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Publication details

The article was received on 27 Dec 2013, accepted on 03 Mar 2014 and first published on 04 Mar 2014


Article type: Paper
DOI: 10.1039/C3NJ01649H
Citation: New J. Chem., 2014,38, 2414-2421
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    Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells

    L. Naso, M. Valcarcel, P. Villacé, M. Roura-Ferrer, C. Salado, E. G. Ferrer and P. A. M. Williams, New J. Chem., 2014, 38, 2414
    DOI: 10.1039/C3NJ01649H

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