Jump to main content
Jump to site search

Issue 1, 2014
Previous Article Next Article

Photophysical study of a π-stacked β-sheet nanofibril forming peptide bolaamphiphile hydrogel

Author affiliations

Abstract

We describe the state of molecular self-assembly of a peptide based bolaamphiphile molecule using spectroscopic and microscopic techniques. The tryptophan and phenylalanine containing peptide bolaamphiphile forms a hydrogel upon sonication under physiological conditions. Sonication helps to reorient the peptide molecules by providing the required energy for the self-assembly process. The disassembly and self-assembly processes are influenced by various stimuli, including heating–cooling and shaking–rest methods. The extensive hydrogen bonding and π–π stacking interactions are responsible for the self-assembly process, which is confirmed by FT-IR, temperature dependent NMR and fluorescence spectroscopy studies. FT-IR and powder X-ray diffraction studies reveal that the gelator molecules self-assemble into an antiparallel β-sheet type structure. The TEM image of the hydrogel shows a well-defined amyloid-like nanofibrillar structure. The amyloid-like behaviour of the fibril forming peptide bolaamphiphile hydrogel is confirmed by ThT and Congo red binding studies. The effect of concentration, time and temperature on the self-assembly mechanism of the peptide bolaamphiphile hydrogel is investigated by time resolved fluorescence spectroscopy.

Graphical abstract: Photophysical study of a π-stacked β-sheet nanofibril forming peptide bolaamphiphile hydrogel

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jul 2013, accepted on 16 Oct 2013 and first published on 17 Oct 2013


Article type: Paper
DOI: 10.1039/C3NJ00814B
Citation: New J. Chem., 2014,38, 376-385
  •   Request permissions

    Photophysical study of a π-stacked β-sheet nanofibril forming peptide bolaamphiphile hydrogel

    I. Maity, T. K. Mukherjee and A. K. Das, New J. Chem., 2014, 38, 376
    DOI: 10.1039/C3NJ00814B

Search articles by author

Spotlight

Advertisements