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Issue 8, 2014
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Macrophages: central regulators of iron balance

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Abstract

Macrophages are important to immune function and also actively participate in iron homeostasis. The involvement of splenic and liver macrophages in the processing of effete erythrocytes and the subsequent return of iron to the circulation is well established, and the molecular details of iron recycling have been characterized recently. Another important aspect regarding iron handling by macrophages is their capacity to act as immune cells, which involves the inflammatory response, as well as other pathological conditions in which macrophages are central. This review discusses the latest advances in macrophage iron trafficking and the pathophysiological consequences of altered iron homeostasis in these cells.

Graphical abstract: Macrophages: central regulators of iron balance

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Publication details

The article was received on 09 Apr 2014, accepted on 29 May 2014 and first published on 29 May 2014


Article type: Minireview
DOI: 10.1039/C4MT00104D
Citation: Metallomics, 2014,6, 1336-1345
  • Open access: Creative Commons BY-NC license
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    Macrophages: central regulators of iron balance

    E. Gammella, P. Buratti, G. Cairo and S. Recalcati, Metallomics, 2014, 6, 1336
    DOI: 10.1039/C4MT00104D

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