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Issue 8, 2014
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Neoglycosylation and neoglycorandomization: enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads

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Abstract

This review focuses upon the development, scope, and utility of the highly versatile chemoselective alkoxyamine-based ‘neoglycosylation’ reaction first described by Peri and Dumy. The fundamentals of neoglycosylation and the subsequent development of a ‘neoglycorandomization’ platform to afford differentially-glycosylated libraries of plant-based natural products, microbial-based natural products, and small molecule-based drugs for drug discovery applications are discussed.

Graphical abstract: Neoglycosylation and neoglycorandomization: enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads

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Publication details

The article was received on 13 Mar 2014, accepted on 23 Apr 2014 and first published on 23 Apr 2014


Article type: Review Article
DOI: 10.1039/C4MD00117F
Author version available: Download Author version (PDF)
Citation: Med. Chem. Commun., 2014,5, 1036-1047
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    Neoglycosylation and neoglycorandomization: enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads

    R. D. Goff and Jon. S. Thorson, Med. Chem. Commun., 2014, 5, 1036
    DOI: 10.1039/C4MD00117F

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