Issue 2, 2015
From the journal:

MedChemComm

A study of a d-proline peptidomimeticinhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9†

Francesca Bianchini,*a   Chiara Calugi,b   Jessica Ruzzolini,a   Gloria Menchi,b   Lido Calorini,a   Antonio Guarnab  and  Andrea Trabocchi*b  

* Corresponding authors

a Department of Clinical and Experimental Biomedical Science “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
E-mail: francesca.bianchini@unifi.it
Fax: +39 055 2751291
Tel: +39 055 2751310

b University of Florence, Department of Chemistry “Ugo Schiff”, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy
E-mail: andrea.trabocchi@unifi.it
Fax: +39 055 4574913
Tel: +39 055 4573507

Abstract

A D-proline peptidomimetic targeting MMP-2 and MMP-9, being involved during tumor cell invasion and angiogenesis, was identified from a pool of compounds following enzyme inhibition kinetics and zymography, clearly highlighting the invasion inhibitory activity and capacity of blocking capillary network formation in vivo.

Graphical abstract: A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9

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Article information

DOI
https://doi.org/10.1039/C4MD00287C
Article type
Concise Article
Submitted
01 Jul 2014
Accepted
20 Oct 2014
First published
21 Oct 2014

Med. Chem. Commun., 2015,6, 277-282

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A study of a D-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9

F. Bianchini, C. Calugi, J. Ruzzolini, G. Menchi, L. Calorini, A. Guarna and A. Trabocchi, Med. Chem. Commun., 2015, 6, 277 DOI: 10.1039/C4MD00287C

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