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Issue 9, 2014
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A versatile acid-labile linker for antibody–drug conjugates

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Abstract

Antibody drug conjugates (ADC) couple therapeutic monoclonal antibodies (mAb) with potent toxins through a linker that is stable within systemic circulation, but cleaves within the target cells. In this report, silyl ether chemistry was used to couple the mAb trastuzumab with the chemotherapeutic, gemcitabine, to demonstrate the use of silyl ethers as a potential linker for ADCs.

Graphical abstract: A versatile acid-labile linker for antibody–drug conjugates

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Publication details

The article was received on 01 Apr 2014, accepted on 13 Jun 2014 and first published on 16 Jun 2014


Article type: Concise Article
DOI: 10.1039/C4MD00150H
Author version available: Download Author version (PDF)
Citation: Med. Chem. Commun., 2014,5, 1355-1358
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    A versatile acid-labile linker for antibody–drug conjugates

    M. C. Finniss, K. S. Chu, C. J. Bowerman, J. C. Luft, Z. A. Haroon and J. M. DeSimone, Med. Chem. Commun., 2014, 5, 1355
    DOI: 10.1039/C4MD00150H

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