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Issue 10, 2014
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Protein–protein interactions of ASPP2: an emerging therapeutic target

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Abstract

The pro-apoptotic ASPP2 protein plays a central role in regulating apoptosis in both p53-dependent and p53-independent pathways. It has become clear in recent years that ASPP2 plays also a role in other important cellular processes like senescence and regulating cell polarity. ASPP2 interacts with numerous proteins in order to exert its pro-apoptotic effect while some other proteins inhibit its pro-apoptotic activity. These interactions are emerging potential targets for activation or inhibition. Drugs that activate ASPP2 may not only induce apoptosis of cancer cells, but also affect other disease-related cellular pathways. Here we review the interactions of ASPP2 with its partner proteins and their potential targeting for drug development.

Graphical abstract: Protein–protein interactions of ASPP2: an emerging therapeutic target

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Publication details

The article was received on 27 Mar 2014, accepted on 13 May 2014 and first published on 14 May 2014


Article type: Review Article
DOI: 10.1039/C4MD00147H
Author version available: Download Author version (PDF)
Citation: Med. Chem. Commun., 2014,5, 1435-1443
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    Protein–protein interactions of ASPP2: an emerging therapeutic target

    A. Iosub-Amir and A. Friedler, Med. Chem. Commun., 2014, 5, 1435
    DOI: 10.1039/C4MD00147H

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