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Issue 7, 2014
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Multivalent glycoconjugates as vaccines and potential drug candidates

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Abstract

Pathogens adhere to the host cells during the first steps of infection through multivalent interactions which involve protein–glycan recognition. Multivalent interactions are also involved at different stages of immune response. Insights into these multivalent interactions generate a way to use suitable carbohydrate ligands that are attached to a basic scaffold consisting of e.g., dendrimer, polymer, nanoparticle, etc., with a suitable linker. Thus a multivalent architecture can be obtained with controllable spatial and topology parameters which can interfere with pathogen adhesion. Multivalent glycoconjugates bearing natural or unnatural carbohydrate antigen epitopes have also been used as carbohydrate based vaccines to stimulate an innate and adaptive immune response. Designing and synthesizing an efficient multivalent architecture with optimal ligand density and a suitable linker is a challenging task. This review presents a concise report on the endeavors to potentially use multi- and polyvalent glycoconjugates as vaccines as well as anti-infectious and anti-inflammatory drug candidates.

Graphical abstract: Multivalent glycoconjugates as vaccines and potential drug candidates

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Publication details

The article was received on 26 Mar 2014, accepted on 13 May 2014 and first published on 16 May 2014


Article type: Review Article
DOI: 10.1039/C4MD00143E
Citation: Med. Chem. Commun., 2014,5, 862-878
  • Open access: Creative Commons BY-NC license
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    Multivalent glycoconjugates as vaccines and potential drug candidates

    S. Bhatia, M. Dimde and R. Haag, Med. Chem. Commun., 2014, 5, 862
    DOI: 10.1039/C4MD00143E

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