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Issue 9, 2014
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NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions

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Abstract

NMR spectroscopy allows the monitoring of molecular recognition processes in solution. Nowadays, a plethora of NMR methods are available to deduce the key features of the interaction from both the ligand or the receptor points of view (receptor-observed or ligand-observed NMR methods, respectively). Herein, we present the most used ligand-observed NMR experiments for drug discovery making special emphasis on their experimental aspects and on their applications to the study of protein–carbohydrate interactions.

Graphical abstract: NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions

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Publication details

The article was received on 25 Mar 2014, accepted on 06 Jun 2014 and first published on 16 Jun 2014


Article type: Review Article
DOI: 10.1039/C4MD00138A
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Citation: Med. Chem. Commun., 2014,5, 1280-1289
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    NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions

    L. Unione, S. Galante, D. Díaz, F. J. Cañada and J. Jiménez-Barbero, Med. Chem. Commun., 2014, 5, 1280
    DOI: 10.1039/C4MD00138A

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