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Issue 8, 2014
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Inhibitors of the human neuraminidase enzymes

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Abstract

The human neuraminidase enzymes (hNEU) are a family of four isoenzymes that hydrolyze sialosides, including gangliosides and glycoproteins. These enzymes are proposed to play roles in several important signaling pathways and are implicated in diseases such as diabetes and cancer. Despite their importance, only a limited number of studies have sought to identify potent inhibitors for these enzymes. This review summarizes the substrate specificity and known inhibitors of the hNEU isoenzymes, as well as the emerging work on development of isoenzyme-specific inhibitors.

Graphical abstract: Inhibitors of the human neuraminidase enzymes

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Publication details

The article was received on 27 Feb 2014, accepted on 20 May 2014 and first published on 18 Jun 2014


Article type: Review Article
DOI: 10.1039/C4MD00089G
Citation: Med. Chem. Commun., 2014,5, 1067-1074
  • Open access: Creative Commons BY license
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    Inhibitors of the human neuraminidase enzymes

    C. W. Cairo, Med. Chem. Commun., 2014, 5, 1067
    DOI: 10.1039/C4MD00089G

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