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Issue 6, 2014
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A comprehensive model of the phototransduction cascade in mouse rod cells

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Abstract

Vertebrate visual phototransduction is perhaps the most well-studied G-protein signaling pathway. A wealth of available biochemical and electrophysiological data has resulted in a rich history of mathematical modeling of the system. However, while the most comprehensive models have relied upon amphibian biochemical and electrophysiological data, modern research typically employs mammalian species, particularly mice, which exhibit significantly faster signaling dynamics. In this work, we present an adaptation of a previously published, comprehensive model of amphibian phototransduction that can produce quantitatively accurate simulations of the murine photoresponse. We demonstrate the ability of the model to predict responses to a wide range of stimuli and under a variety of mutant conditions. Finally, we employ the model to highlight a likely unknown mechanism related to the interaction between rhodopsin and rhodopsin kinase.

Graphical abstract: A comprehensive model of the phototransduction cascade in mouse rod cells

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Publication details

The article was received on 12 Dec 2013, accepted on 20 Mar 2014 and first published on 20 Mar 2014


Article type: Paper
DOI: 10.1039/C3MB70584F
Citation: Mol. BioSyst., 2014,10, 1481-1489
  • Open access: Creative Commons BY-NC license
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    A comprehensive model of the phototransduction cascade in mouse rod cells

    B. M. Invergo, D. Dell'Orco, L. Montanucci, K. Koch and J. Bertranpetit, Mol. BioSyst., 2014, 10, 1481
    DOI: 10.1039/C3MB70584F

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      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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      [Original citation] - Published by The Royal Society of Chemistry.

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