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Issue 5, 2014
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Latex micro-balloon pumping in centrifugal microfluidic platforms

Mohammad Mahdi Aeinehvand,ab  Fatimah Ibrahim,*ab  Sulaiman Wadi harun,cd  Wisam Al-Faqheri,a  Tzer Hwai Gilbert Thio,ab  Amin Kazemzadehabe  and  Marc Madouabfgh 
Author affiliations

* Corresponding authors

a Center for Innovation in Medical Engineering (CIME), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
E-mail: fatimah@um.edu.my
Fax: +60 3 7967 4579
Tel: +60 3 7967 6818

b Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia

c Department of Electrical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia

d Photonic Research Centre, Department of Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

e Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia

f Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

g Department of Biomedical Engineering, University of California, Irvine, Irvine, USA

h Department of Mechanical and Aerospace Engineering, University of California, Irvine, Irvine, USA

Abstract

Centrifugal microfluidic platforms have emerged as point-of-care diagnostic tools. However, the unidirectional nature of the centrifugal force limits the available space for multi-step processes on a single microfluidic disc. To overcome this limitation, a passive pneumatic pumping method actuated at high rotational speeds has been previously proposed to pump liquid against the centrifugal force. In this paper, a novel micro-balloon pumping method that relies on elastic energy stored in a latex membrane is introduced. It operates at low rotational speeds and pumps a larger volume of liquid towards the centre of the disc. Two different micro-balloon pumping mechanisms have been designed to study the pump performance at a range of rotational frequencies from 0 to 1500 rpm. The behaviour of the micro-balloon pump on the centrifugal microfluidic platforms has been theoretically analysed and compared with the experimental data. The experimental data show that the developed pumping method dramatically decreases the required rotational speed to pump liquid compared to the previously developed pneumatic pumping methods. It also shows that within a range of rotational speed, a desirable volume of liquid can be stored and pumped by adjusting the size of the micro-balloon.

Graphical abstract: Latex micro-balloon pumping in centrifugal microfluidic platforms

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Publication details

The article was received on 02 Oct 2013, accepted on 02 Dec 2013 and first published on 02 Dec 2013


Article type: Paper
DOI: 10.1039/C3LC51116B
Citation: Lab Chip, 2014,14, 988-997
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    Latex micro-balloon pumping in centrifugal microfluidic platforms

    M. M. Aeinehvand, F. Ibrahim, S. W. harun, W. Al-Faqheri, T. H. G. Thio, A. Kazemzadeh and M. Madou, Lab Chip, 2014, 14, 988
    DOI: 10.1039/C3LC51116B

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