Jump to main content
Jump to site search

Issue 10, 2014
Previous Article Next Article

Acoustic bubble sorting for ultrasound contrast agent enrichment

Author affiliations

Abstract

An ultrasound contrast agent (UCA) suspension contains encapsulated microbubbles with a wide size distribution, with radii ranging from 1 to 10 μm. Medical transducers typically operate at a single frequency, therefore only a small selection of bubbles will resonate to the driving ultrasound pulse. Thus, the sensitivity can be improved by narrowing down the size distribution. Here, we present a simple lab-on-a-chip method to sort the population of microbubbles on-chip using a traveling ultrasound wave. First, we explore the physical parameter space of acoustic bubble sorting using well-defined bubble sizes formed in a flow-focusing device, then we demonstrate successful acoustic sorting of a commercial UCA. This novel sorting strategy may lead to an overall improvement of the sensitivity of contrast ultrasound by more than 10 dB.

Graphical abstract: Acoustic bubble sorting for ultrasound contrast agent enrichment

Back to tab navigation

Publication details

The article was received on 20 Nov 2013, accepted on 07 Feb 2014 and first published on 07 Feb 2014


Article type: Paper
DOI: 10.1039/C3LC51296G
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2014,14, 1705-1714
  •   Request permissions

    Acoustic bubble sorting for ultrasound contrast agent enrichment

    T. Segers and M. Versluis, Lab Chip, 2014, 14, 1705
    DOI: 10.1039/C3LC51296G

Search articles by author

Spotlight

Advertisements