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Issue 5, 2014
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Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip

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Abstract

Radiotracer synthesis is an ideal application for microfluidics because only nanogram quantities are needed for positron emission tomography (PET) imaging. Thousands of radiotracers have been developed in research settings but only a few are readily available, severely limiting the biological problems that can be studied in vivo via PET. We report the development of an electrowetting-on-dielectric (EWOD) digital microfluidic chip that can synthesize a variety of 18F-labeled tracers targeting a range of biological processes by confirming complete syntheses of four radiotracers: a sugar, a DNA nucleoside, a protein labelling compound, and a neurotransmitter. The chip employs concentric multifunctional electrodes that are used for heating, temperature sensing, and EWOD actuation. All of the key synthesis steps for each of the four 18F-labeled tracers are demonstrated and characterized with the chip: concentration of fluoride ion, solvent exchange, and chemical reactions. The obtained fluorination efficiencies of 90–95% are comparable to, or greater than, those achieved by conventional approaches.

Graphical abstract: Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip

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Publication details

The article was received on 22 Oct 2013, accepted on 05 Dec 2013 and first published on 05 Dec 2013


Article type: Paper
DOI: 10.1039/C3LC51195B
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2014,14, 902-910
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    Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip

    S. Chen, M. R. Javed, H. Kim, J. Lei, M. Lazari, G. J. Shah, R. M. van Dam, P. Keng and C. “. Kim, Lab Chip, 2014, 14, 902
    DOI: 10.1039/C3LC51195B

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