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Issue 3, 2014
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Multiscale immunomagnetic enrichment of circulating tumor cells: from tubes to microchips

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Abstract

We review the rare cancer cell sorting technologies, with a focus on multiscale immunomagnetic approaches. Starting from the conventional magnetic activated cell sorting system, we derive the scaling laws of immunomagnetic assay and justify the recent trend of using downscaled systems for CTC studies. Furthermore, we introduce recent work on combining the immunomagnetic assay with microfluidic technology for enhanced separation. We summarize different types of in-channel micro-magnetic structures that can further increase the local magnetic field without lowering the system throughput. Related design concepts, principles, and microfabrication techniques are presented and evaluated.

Graphical abstract: Multiscale immunomagnetic enrichment of circulating tumor cells: from tubes to microchips

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Publication details

The article was received on 30 Sep 2013, accepted on 12 Nov 2013 and first published on 02 Dec 2013


Article type: Critical Review
DOI: 10.1039/C3LC51107C
Citation: Lab Chip, 2014,14, 446-458
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    Multiscale immunomagnetic enrichment of circulating tumor cells: from tubes to microchips

    P. Chen, Y. Huang, K. Hoshino and X. Zhang, Lab Chip, 2014, 14, 446
    DOI: 10.1039/C3LC51107C

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