Jump to main content
Jump to site search

Issue 3, 2014
Previous Article Next Article

Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems

Author affiliations

Abstract

We developed a microfluidic flow-control system capable of dynamically generating various flow patterns on demand. The flow-control system is based on novel magnetoactive sponges embedded in microfluidic flow channels. Applying a non-uniform magnetic field compresses the magnetoactive sponge, significantly reducing porosity and hydraulic conductivity. Tuning the applied magnetic field can dynamically vary the flow rate in the microfluidic channel. Pulsatile and physiological flow patterns with frequency between 1 and 3 Hz, flow rates between 0.5 and 10 μL min−1 and duration over 3 weeks have been achieved. Smooth muscle cells in engineered blood vessels perfused for 7 days aligned perpendicular to the flow direction under pulsatile but not steady flow, similar to the in vivo orientation. Owing to its various advantages over traditional flow-control methods, the new system potentially has important applications in microfluidic-based microphysiological systems to simulate the physiological nature of blood flow.

Graphical abstract: Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Sep 2013, accepted on 25 Nov 2013 and first published on 25 Nov 2013


Article type: Paper
DOI: 10.1039/C3LC51076J
Citation: Lab Chip, 2014,14, 514-521
  •   Request permissions

    Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems

    S. Hong, Y. Jung, R. Yen, H. F. Chan, K. W. Leong, G. A. Truskey and X. Zhao, Lab Chip, 2014, 14, 514
    DOI: 10.1039/C3LC51076J

Search articles by author

Spotlight

Advertisements