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Issue 3, 2014
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A novel tool for dynamic cell adhesion studies – the De-Adhesion Number Investigator DANI

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Abstract

For an optimal implementation of materials, such as, e.g. medical implants in living environments, a thorough characterization of cell adhesion, kinetics and strength is required, as well as a prerequisite e.g. for bone integration. Here we present a miniaturized (~100 μl) lab-on-a-chip implant hybrid system which allows quantification of cell adhesion under dynamic conditions mimicking those of physiological relevance. Surface acoustic waves are excited and used on optical transparent chips to induce micro acoustic streaming and to create a microfluidic shear spectrum ranging from 0 to ~35 s−1. We demonstrate its potential for a time-efficient, dynamic screening test of new implant materials using a model of an osseointegration with SAOS-2 cells. The upside-down orientation also allows utilization of the micro reactor on non-transparent materials like titanium and diamond-like-carbon (DLC).

Graphical abstract: A novel tool for dynamic cell adhesion studies – the De-Adhesion Number Investigator DANI

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Publication details

The article was received on 06 Aug 2013, accepted on 08 Nov 2013 and first published on 11 Nov 2013


Article type: Paper
DOI: 10.1039/C3LC50916H
Citation: Lab Chip, 2014,14, 542-546
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    A novel tool for dynamic cell adhesion studies – the De-Adhesion Number Investigator DANI

    A. Hartmann, M. Stamp, R. Kmeth, S. Buchegger, B. Stritzker, B. Saldamli, R. Burgkart, M. F. Schneider and A. Wixforth, Lab Chip, 2014, 14, 542
    DOI: 10.1039/C3LC50916H

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