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Issue 3, 2014
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Unraveling intestinal stem cell behavior with models of crypt dynamics

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Abstract

The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated. Recent discoveries have started to clarify the nature of ISCs, but many questions remain. This review discusses the current advances and controversies of ISC biology as well as theoretical compartmental models that have been coupled with in vivo experimentation to investigate the mechanisms of ISC dynamics during homeostasis, tumorigenesis, repair and development. We conclude our review by discussing the key lingering questions in the field and proposing how many of these questions can be addressed using both compartmental models and experimental techniques.

Graphical abstract: Unraveling intestinal stem cell behavior with models of crypt dynamics

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Publication details

The article was received on 10 Aug 2013, accepted on 21 Jan 2014 and first published on 21 Jan 2014


Article type: Critical Review
DOI: 10.1039/C3IB40163D
Citation: Integr. Biol., 2014,6, 243-257
  • Open access: Creative Commons BY license
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    Unraveling intestinal stem cell behavior with models of crypt dynamics

    A. J. Carulli, L. C. Samuelson and S. Schnell, Integr. Biol., 2014, 6, 243
    DOI: 10.1039/C3IB40163D

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