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Issue 8, 2014
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The EGFR demonstrates linear signal transmission

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Cells sense information encoded in extracellular ligand concentrations and process it using intracellular signalling cascades. Using mathematical modelling and high-throughput imaging of individual cells, we studied how a transient extracellular growth factor signal is sensed by the epidermal growth factor receptor system, processed by downstream signalling, and transmitted to the nucleus. We found that transient epidermal growth factor signals are linearly translated into an activated epidermal growth factor receptor integrated over time. This allows us to generate a simplified model of receptor signaling where the receptor acts as a perfect sensor of extracellular information, while the nonlinear input–output relationship of EGF-EGFR triggered signalling is a consequence of the downstream MAPK cascade alone.

Graphical abstract: The EGFR demonstrates linear signal transmission

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The article was received on 21 Mar 2014, accepted on 01 Jun 2014 and first published on 03 Jun 2014

Article type: Paper
DOI: 10.1039/C4IB00062E
Author version available: Download Author version (PDF)
Citation: Integr. Biol., 2014,6, 736-742
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    The EGFR demonstrates linear signal transmission

    D. A. Oyarzún, J. L. Bramhall, F. López-Caamal, F. M. Richards, D. I. Jodrell and B. Krippendorff, Integr. Biol., 2014, 6, 736
    DOI: 10.1039/C4IB00062E

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