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Issue 6, 2014
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Multicomponent reactions: advanced tools for sustainable organic synthesis

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Abstract

Sustainable or green chemistry has established firm ground providing essential design criteria for the development of efficient chemical syntheses of complex, high added value molecules. On the other hand, multicomponent reactions have only recently been recognized as major expansion of the synthetic chemist's toolbox. There is still little awareness, however, of the practical value of these type of reactions for meeting many of the criteria set by the green chemistry philosophy to guide organic chemists and process chemists in the design, synthesis and further development of truly sustainable manufacturing processes of medicines, food additives, catalysts or advanced materials. In this perspective we highlight the utility of multicomponent reactions as methods for green synthesis.

Graphical abstract: Multicomponent reactions: advanced tools for sustainable organic synthesis

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Publication details

The article was received on 05 Jan 2014, accepted on 18 Feb 2014 and first published on 19 Feb 2014


Article type: Perspective
DOI: 10.1039/C4GC00013G
Author version available: Download Author version (PDF)
Citation: Green Chem., 2014,16, 2958-2975
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    Multicomponent reactions: advanced tools for sustainable organic synthesis

    R. C. Cioc, E. Ruijter and R. V. A. Orru, Green Chem., 2014, 16, 2958
    DOI: 10.1039/C4GC00013G

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