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Issue 3, 2014
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Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase

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Abstract

The conversion of the phenolic monoterpenes thymol and carvacrol into antimicrobials by (electro)-chemoenzymatic halogenation was investigated using a chloroperoxidase (CPO) catalyzed process. The CPO catalysed process enables for the first time the biotechnological production of chlorothymol, chlorocarvacrol and bromothymol as well as a dichlorothymol with high conversion rates, total turnover numbers and space time yields of up to 90%, 164 000 and 4.6 mM h−1, respectively.

Graphical abstract: Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase

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Publication details

The article was received on 04 Nov 2013, accepted on 28 Nov 2013 and first published on 28 Nov 2013


Article type: Communication
DOI: 10.1039/C3GC42269K
Citation: Green Chem., 2014,16, 1104-1108
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    Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase

    L. Getrey, T. Krieg, F. Hollmann, J. Schrader and D. Holtmann, Green Chem., 2014, 16, 1104
    DOI: 10.1039/C3GC42269K

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