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Issue 3, 2014
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Cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides via palladium-catalyzed carbonylation reaction

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Abstract

A cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides through a palladium-catalyzed carbonylation reaction has been developed. Various quinazolinones were produced in moderate to excellent yields. The reactions go through aminocarbonylation of aryl bromides–hydration of nitriles–cyclization sequence. Notably, all the products were isolated by recrystallization.

Graphical abstract: Cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides via palladium-catalyzed carbonylation reaction

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Publication details

The article was received on 08 Oct 2013, accepted on 06 Nov 2013 and first published on 07 Nov 2013


Article type: Paper
DOI: 10.1039/C3GC42089B
Citation: Green Chem., 2014,16, 1336-1343
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    Cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides via palladium-catalyzed carbonylation reaction

    H. Li, L. He, H. Neumann, M. Beller and X. Wu, Green Chem., 2014, 16, 1336
    DOI: 10.1039/C3GC42089B

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