Issue 7, 2014
From the journal:

Food & Function

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

Marta Oliveira,†abc   Filipa S. Reis,†de   Diana Sousa,d   Catarina Tavares,d   Raquel T. Lima,df   Isabel C. F. R. Ferreira,*e   Tiago dos Santosd  and  M. Helena Vasconcelos*cd  

* Corresponding authors

a Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

b Faculty of Sciences of the University of Porto (FCUP), Porto, Portugal

c Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy of the University of Porto (FFUP), Portugal

d Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
E-mail: hvasconcelos@ipatimup.pt
Fax: +351-225570799
Tel: +351-225570700

e Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal
E-mail: iferreira@ipb.pt
Fax: +351-273-325405
Tel: +351-273-303219

f Centre of Medicinal Chemistry of the University of Porto (CEQUIMED-UP), Porto, Portugal

Abstract

Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line (AGS) by interfering with cellular autophagy and cell cycle.

Graphical abstract: A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

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Article information

DOI
https://doi.org/10.1039/C4FO00258J
Article type
Paper
Submitted
25 Mar 2014
Accepted
23 Apr 2014
First published
24 Apr 2014

Food Funct., 2014,5, 1389-1394

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A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

M. Oliveira, F. S. Reis, D. Sousa, C. Tavares, R. T. Lima, I. C. F. R. Ferreira, T. D. Santos and M. H. Vasconcelos, Food Funct., 2014, 5, 1389 DOI: 10.1039/C4FO00258J

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