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Issue 9, 2014
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Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions in D-galactose-induced BALB/c mice

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Abstract

The oral administration of Asn-Trp (NW) or carnosine (β-alanyl-L-histidine) dipeptides to D-galactose (Gal)-induced BALB/c mice was used to evaluate antioxidant activities in vivo. D-Galactose (Gal) was subcutaneously injected into the dorsal necks of mice daily for eight weeks to induce oxidative stress (Gal group). From the beginning of the fifth week, groups of NW10, NW40 (10 or 40 mg NW kg−1) or carnosine40 (40 mg carnosine kg−1) were administered orally concurrent Gal injection until the end of studies. It was found that the malondialdehyde (MDA) contents in these intervention groups were much lower than the Gal group. The mice in the NW40 group showed significant improvements compared to the Gal group in a reference memory task and probe trial test evaluated by Morris water maze. Mice in the intervention groups showed higher GSH levels and oxygen radical antioxidant capacity activities and lower MDA levels in the brain or liver tissues compared to the Gal group. The levels of advanced glycation end-products, including Nε-(carboxymethyl)lysine (CML) and argpyrimidine, in the brain tissues of the NW40 interventions are significantly lower compared to the Gal group. These results suggest that NW may be useful in developing functional foods for antioxidant and anti-aging purposes.

Graphical abstract: Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions in d-galactose-induced BALB/c mice

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Publication details

The article was received on 12 Mar 2014, accepted on 29 Jun 2014 and first published on 30 Jun 2014


Article type: Paper
DOI: 10.1039/C4FO00205A
Author version available: Download Author version (PDF)
Citation: Food Funct., 2014,5, 2228-2236
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    Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions in D-galactose-induced BALB/c mice

    C. Han, Y. Lin, T. Lee, H. Liang and W. Hou, Food Funct., 2014, 5, 2228
    DOI: 10.1039/C4FO00205A

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