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Issue 1, 2014
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Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels

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Abstract

Astaxanthin (AST) is a carotenoid pigment which possesses potent antioxidative, anti-inflammatory, and neuroprotective properties. The aim of this study was to investigate whether administration of AST had protective effects on D-galactose-induced brain aging in rats, and further examined its protective mechanisms. The results showed that AST treatment significantly restored the activities of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD), and increased glutathione (GSH) contents and total antioxidant capacity (T-AOC), but decreased malondialdehyde (MDA), protein carbonylation and 8-hydroxy-2- deoxyguanosine (8-OHdG) levels in the brains of aging rats. Furthermore, AST increased the ratio of Bcl-2/Bax, but decreased the expression of Cyclooxygenase-2 (COX-2) in the brains of aging rats. Additionally, AST ameliorated histopathological changes in the hippocampus and restored brain derived neurotrophic factor (BDNF) levels in both the brains and hippocampus of aging rats. These results suggested that AST could alleviate brain aging, which may be due to attenuating oxidative stress, ameliorating hippocampus damage, and upregulating BDNF expression.

Graphical abstract: Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels

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Publication details

The article was received on 09 Sep 2013, accepted on 09 Nov 2013 and first published on 11 Nov 2013


Article type: Paper
DOI: 10.1039/C3FO60400D
Citation: Food Funct., 2014,5, 158-166
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    Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels

    W. Wu, X. Wang, Q. Xiang, X. Meng, Y. Peng, N. Du, Z. Liu, Q. Sun, C. Wang and X. Liu, Food Funct., 2014, 5, 158
    DOI: 10.1039/C3FO60400D

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