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Volume 170, 2014
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Introductory Lecture: Mechanochemistry, a versatile synthesis strategy for new materials

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Abstract

Mechanochemistry deals with reactions induced by the input of mechanical energy – for example by impacts within a vibratory ball mill. The technique has a long history with significant contributions from Ostwald, Carey Lea and, notably, Faraday. Mechanochemistry has subsequently seen application in a variety of areas of materials science including mechanical alloying in metallurgy, the synthesis of complex organic molecules and, more recently, the discovery and development of new solid forms of active pharmaceutical ingredients. This paper overviews the broad areas of application of mechanochemistry, some key features which make it a particularly attractive approach to materials synthesis and some mechanistic aspects highlighted within the literature. A significant part, however, will focus on recent applications in the area of pharmaceuticals and its important role in exploring the rich variety of solid forms available for small, drug-like, molecules.

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Publication details

The article was received on 28 Aug 2014, accepted on 02 Sep 2014, published on 02 Sep 2014 and first published online on 02 Sep 2014


Article type: Paper
DOI: 10.1039/C4FD00162A
Citation: Faraday Discuss., 2014,170, 9-34
  • Open access: Creative Commons BY license
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    Introductory Lecture: Mechanochemistry, a versatile synthesis strategy for new materials

    W. Jones and M. D. Eddleston, Faraday Discuss., 2014, 170, 9
    DOI: 10.1039/C4FD00162A

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