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Issue 26, 2014
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Pros and cons of bifunctional platinum(IV) antitumor prodrugs: two are (not always) better than one

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Abstract

This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(IV) octahedral core and one or more bioactive molecules. The platinum(IV) complexes release upon reduction the corresponding cytotoxic Pt(II) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(II) metabolites.

Graphical abstract: Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

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Publication details

The article was received on 27 Mar 2014, accepted on 12 May 2014 and first published on 12 May 2014


Article type: Perspective
DOI: 10.1039/C4DT00911H
Citation: Dalton Trans., 2014,43, 9813-9820
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    Pros and cons of bifunctional platinum(IV) antitumor prodrugs: two are (not always) better than one

    E. Gabano, M. Ravera and D. Osella, Dalton Trans., 2014, 43, 9813
    DOI: 10.1039/C4DT00911H

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