Issue 26, 2014

Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Abstract

This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(IV) octahedral core and one or more bioactive molecules. The platinum(IV) complexes release upon reduction the corresponding cytotoxic Pt(II) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(II) metabolites.

Graphical abstract: Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Article information

Article type
Perspective
Submitted
27 Mar 2014
Accepted
12 May 2014
First published
12 May 2014

Dalton Trans., 2014,43, 9813-9820

Pros and cons of bifunctional platinum(IV) antitumor prodrugs: two are (not always) better than one

E. Gabano, M. Ravera and D. Osella, Dalton Trans., 2014, 43, 9813 DOI: 10.1039/C4DT00911H

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