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Issue 25, 2014
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A highly selective and sensitive turn-on chemodosimeter for hypochlorous acid based on an iridium(III) complex and its application to bioimaging

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Abstract

A novel and easily accessible luminescent iridium(III) complex [Ir(tpy)2(N^N)]PF6 (Ir-ANMM, tpy = 2-(p-tolyl)pyridine, N^N = 4-[(4-amino-3-nitrophenoxy)-methylene]-4′-methyl-2,2′-bipyridine) for the sensing of HOCl has been designed and synthesized. The detection strategy is based on the HOCl-promoted cleavage of the PET quenching 4-amino-3-nitrophenyloxy moiety of the weakly emissive complex Ir-ANMM, which gives rise to a highly luminescent complex [Ir(tpy)2(N^N′)]PF6 (Ir-HM, N^N′ = 4-hydroxymethyl-4′-methyl-2,2′-bipyridine). Comparisons of the absorption, emission and mass spectra of Ir-ANMM in the absence and presence of HOCl have all confirmed the transformation of Ir-ANMM to Ir-HM. Titration and competition experiments have revealed high sensitivity and high selectivity of Ir-ANMM for HOCl, respectively. Significantly, the feasibility of the sensor under physiological conditions enables the successful luminescent imaging of HOCl in HeLa cells.

Graphical abstract: A highly selective and sensitive turn-on chemodosimeter for hypochlorous acid based on an iridium(iii) complex and its application to bioimaging

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Publication details

The article was received on 28 Feb 2014, accepted on 10 Apr 2014 and first published on 11 Apr 2014


Article type: Paper
DOI: 10.1039/C4DT00616J
Citation: Dalton Trans., 2014,43, 9529-9536
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    A highly selective and sensitive turn-on chemodosimeter for hypochlorous acid based on an iridium(III) complex and its application to bioimaging

    F. Lu and T. Nabeshima, Dalton Trans., 2014, 43, 9529
    DOI: 10.1039/C4DT00616J

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