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Issue 26, 2014
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Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent

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Abstract

A water-stable phosphoramidate Ru(arene) metallodrug shows antiproliferative activity comparable to KP1019 in human cancer cell lines. This novel compound can cross-link the peptide backbone of cytochrome c, but features low apoptosis inducing properties.

Graphical abstract: Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent

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Publication details

The article was received on 24 Feb 2014, accepted on 02 May 2014 and first published on 06 May 2014


Article type: Communication
DOI: 10.1039/C4DT00569D
Citation: Dalton Trans., 2014,43, 9851-9855
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    Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent

    S. M. Meier, M. S. Novak, W. Kandioller, M. A. Jakupec, A. Roller, B. K. Keppler and C. G. Hartinger, Dalton Trans., 2014, 43, 9851
    DOI: 10.1039/C4DT00569D

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