Jump to main content
Jump to site search

Issue 24, 2014
Previous Article Next Article

Structural characterization and biological evaluation of a clioquinol–ruthenium complex with copper-independent antileukaemic activity

Author affiliations

Abstract

In this study, we present the synthesis, biological characterization, and first crystal structure of an organometallic–clioquinol complex. Combining ruthenium with the established apoptotic agent and 8-hydroxyquinoline derivative, clioquinol, resulted in a complex that induces caspase-dependent cell death in leukaemia cells. This activity is copper independent and is improved compared to the parent compound, clioquinol. The study of the mode of action reveals that this clioquinol–ruthenium complex does not intercalate between DNA base pairs. Additionally, this clioquinol–ruthenium complex shows proteasome-independent inhibition of the NFκB signalling pathway, with no effects on cell-cycle distribution. These data suggest a mechanism of action that involves a target profile that is different from that for clioquinol alone.

Graphical abstract: Structural characterization and biological evaluation of a clioquinol–ruthenium complex with copper-independent antileukaemic activity

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Feb 2014, accepted on 04 Apr 2014 and first published on 04 Apr 2014


Article type: Paper
DOI: 10.1039/C4DT00463A
Citation: Dalton Trans., 2014,43, 9045-9051
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Structural characterization and biological evaluation of a clioquinol–ruthenium complex with copper-independent antileukaemic activity

    M. Gobec, J. Kljun, I. Sosič, I. Mlinarič-Raščan, M. Uršič, S. Gobec and I. Turel, Dalton Trans., 2014, 43, 9045
    DOI: 10.1039/C4DT00463A

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements