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Issue 3, 2014
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Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe

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Abstract

Three-component nanocomposites, constituted by a superparamagnetic iron oxide core coated with a polymeric surfactant bearing tightly bound Re(CO)3 moieties, were prepared and fully characterized. The water soluble and biocompatible surfactant was a linear poly(amidoamine) copolymer (PAA), containing cysteamine pendants in the minority part (ISA23SH), able to coordinate Re(CO)3 fragments. For the synthesis of the nanocomposites two methods were compared, involving either (i) peptization of bare magnetite nanoparticles by interaction with the preformed ISA23SH-Re(CO)3 complex, or (ii) “one-pot” synthesis of iron oxide nanoparticles in the presence of the ISA23SH copolymer, followed by complexation of Re to the SPIO@ISA23SH nanocomposite. Full characterization by TEM, DLS, TGA, SQUID, and relaxometry showed that the second method gave better results. The magnetic cores had a roundish shape, with low dispersion (mean diameter ca. 6 nm) and a tendency to form larger aggregates (detected both by TEM and DLS), arising from multiple interactions of the polymeric coils. Aggregation did not affect the stability of the nano-suspension, found to be stable for many months without precipitate formation. The SPIO@PAA-Re nanoparticles (NPs) showed superparamagnetic behaviour and nuclear relaxivities similar or superior to commercial MRI contrast agents (CAs), which make them promising as MRI “negative” CAs. The possibility to encapsulate 186/188Re isotopes (γ and β emitters) gives these novel NPs the potential to behave as bimodal nanostructures devoted to theranostic applications.

Graphical abstract: Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe

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Publication details

The article was received on 28 Aug 2013, accepted on 15 Oct 2013 and first published on 16 Oct 2013


Article type: Paper
DOI: 10.1039/C3DT52377B
Citation: Dalton Trans., 2014,43, 1172-1183
  • Open access: Creative Commons BY-NC license
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    Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe

    D. Maggioni, P. Arosio, F. Orsini, A. M. Ferretti, T. Orlando, A. Manfredi, E. Ranucci, P. Ferruti, G. D'Alfonso and A. Lascialfari, Dalton Trans., 2014, 43, 1172
    DOI: 10.1039/C3DT52377B

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