Unprecedented dinuclear silver(I)-mediated base pair involving the DNA lesion 1,N6-ethenoadenine

Soham Mandal; Alexander Hepp; Jens Müller

doi:10.1039/C4DT02663B

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Unprecedented dinuclear silver(i)-mediated base pair involving the DNA lesion 1,N⁶-ethenoadenine†

Soham Mandal,^ab Alexander Hepp^a and Jens Müller*^ab

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* Corresponding authors

^a Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstr. 28/30, 48149 Münster, Germany
E-mail: mueller.j@uni-muenster.de
Fax: +49 251 8336007
Tel: +49 251 8336006

^b Westfälische Wilhelms-Universität Münster, NRW Graduate School of Chemistry, Corrensstr. 28/30, 48149 Münster, Germany

Abstract

The DNA lesion 1,N⁶-ethenoadenine (εA) has been investigated with respect to its metal-binding properties. A synthetic DNA duplex comprising an εA : εA mispair readily forms doubly silver(I)-mediated base pairs εA–Ag(I)₂–εA, representing the first example for a dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.

This article is part of the themed collection: Metal Interactions with Nucleic Acids

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Article information

DOI: https://doi.org/10.1039/C4DT02663B
Article type: Communication
Submitted: 01 Sep 2014
Accepted: 27 Nov 2014
First published: 28 Nov 2014
This article is Open Access

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Dalton Trans., 2015,44, 3540-3543

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Unprecedented dinuclear silver(I)-mediated base pair involving the DNA lesion 1,N⁶-ethenoadenine

S. Mandal, A. Hepp and J. Müller, Dalton Trans., 2015, 44, 3540 DOI: 10.1039/C4DT02663B

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