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Issue 32, 2014
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NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

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Abstract

We report here that the established anticancer ruthenium(III) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a “non-cytotoxic” antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.

Graphical abstract: NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

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Publication details

The article was received on 07 May 2014, accepted on 16 Jun 2014 and first published on 16 Jun 2014


Article type: Communication
DOI: 10.1039/C4DT01356E
Citation: Dalton Trans., 2014,43, 12150-12155
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    NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

    S. Pillozzi, L. Gasparoli, M. Stefanini, M. Ristori, M. D'Amico, E. Alessio, F. Scaletti, A. Becchetti, A. Arcangeli and L. Messori, Dalton Trans., 2014, 43, 12150
    DOI: 10.1039/C4DT01356E

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