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Issue 26, 2014
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Targeting cytotoxicity and tubulin polymerization by metal–carbene complexes on a purine tautomer platform

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Abstract

This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(I) and Hg(II)–carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site.

Graphical abstract: Targeting cytotoxicity and tubulin polymerization by metal–carbene complexes on a purine tautomer platform

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Publication details

The article was received on 20 Feb 2014, accepted on 09 Apr 2014 and first published on 09 Apr 2014


Article type: Communication
DOI: 10.1039/C4DT00529E
Citation: Dalton Trans., 2014,43, 9838-9842
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    Targeting cytotoxicity and tubulin polymerization by metal–carbene complexes on a purine tautomer platform

    S. Khanna, B. Jana, A. Saha, P. Kurkute, S. Ghosh and S. Verma, Dalton Trans., 2014, 43, 9838
    DOI: 10.1039/C4DT00529E

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