Jump to main content
Jump to site search

Issue 23, 2014
Previous Article Next Article

New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe

Author affiliations

Abstract

Five manganese(I) tricarbonyl complexes of the general formulae [Mn(bpeaN[double bond, length as m-dash]CHC6H4R)(CO)3]PF6 and [Mn(bpeaNHCH2C6H4R)(CO)3]PF6 based on the tridentate bis(pyrazolyl)ethylamine (bpea) ligand, each containing a pendant 4-substituted phenyl group with R = H, I, and C[triple bond, length as m-dash]C–H, were synthesized and fully characterized, including X-ray structure analysis for three compounds. All complexes are stable in the dark in aqueous buffer for an extended period of time. However, CO-release could be triggered by illumination at 365 nm, establishing these compounds as novel photoactivatable CO-releasing molecules (PhotoCORMs). The influence of the imine vs. amine group in the ligands on the electronic structure and the photophysical behavior was investigated with the aid of DFT and TDDFT calculations. Solution IR studies on selected compounds allowed identification of intermediates resulting from the photoreaction. Finally, light-induced CO release from a model compound was demonstrated both in PBS buffer and in vitro in human umbilical vein endothelial cells (HUVECs) using COP-1 as a fluorescent switch-on probe.

Graphical abstract: New modular manganese(i) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 23 Jan 2014, accepted on 01 Mar 2014, published on 03 Mar 2014 and first published online on 03 Mar 2014


Article type: Paper
DOI: 10.1039/C4DT00254G
Citation: Dalton Trans., 2014,43, 8664-8678
  •   Request permissions

    New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe

    S. Pai, M. Hafftlang, G. Atongo, C. Nagel, J. Niesel, S. Botov, H. Schmalz, B. Yard and U. Schatzschneider, Dalton Trans., 2014, 43, 8664
    DOI: 10.1039/C4DT00254G

Search articles by author