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Issue 19, 2014
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Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

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Abstract

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

Graphical abstract: Dinuclear zinc(ii) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

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Publication details

The article was received on 20 Jan 2014, accepted on 27 Feb 2014 and first published on 03 Mar 2014


Article type: Communication
DOI: 10.1039/C4DT00198B
Citation: Dalton Trans., 2014,43, 6973-6976
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    Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

    Q. Xie, S. Liu, X. Li, Q. Wu, Z. Luo, X. Fu, W. Cao, G. Lan, D. Li, W. Zheng and T. Chen, Dalton Trans., 2014, 43, 6973
    DOI: 10.1039/C4DT00198B

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