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Issue 17, 2014
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A tetrazole-based fluorescence “turn-on” sensor for Al(III) and Zn(II) ions and its application in bioimaging

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Abstract

A tetrazole derivative 1-[(1H-tetrazol-5-ylimino)methyl]naphthalen-2-ol (H2L) as a fluorescent chemosensor for Al3+ in DMSO and Zn2+ in DMF was designed and synthesized. From 1H NMR data, the Job plot and the ESI-MS spectrum, 1 : 1 stoichiometric complexation between H2L and Al3+/Zn2+ was found in DMSO and DMF, respectively. The theoretical calculations at the level of B3LYP/6-311G** for the ground state and TD-B3LYP/6-311G** for the excited state revealed the sensing mechanism is the inhibition of excited state intramolecular proton transfer (ESIPT). And the possible fluorescent species formed in the DMSO and DMF solutions were deduced to be [Al(HL)(OH)(NO3)(H2O)(DMSO)] and [Zn(HL)(OH)(H2O)(DMF)]. What's more, it is confirmed that H2L could be used to detect Al3+ and Zn2+ in cells by bioimaging.

Graphical abstract: A tetrazole-based fluorescence “turn-on” sensor for Al(iii) and Zn(ii) ions and its application in bioimaging

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Publication details

The article was received on 03 Jan 2014, accepted on 12 Feb 2014 and first published on 12 Feb 2014


Article type: Paper
DOI: 10.1039/C4DT00009A
Author version available: Download Author version (PDF)
Citation: Dalton Trans., 2014,43, 6429-6435
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    A tetrazole-based fluorescence “turn-on” sensor for Al(III) and Zn(II) ions and its application in bioimaging

    W. Ding, W. Cao, X. Zheng, W. Ding, J. Qiao and L. Jin, Dalton Trans., 2014, 43, 6429
    DOI: 10.1039/C4DT00009A

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