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Issue 21, 2014
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Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors

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Abstract

Two novel ruthenium polypyridyl complexes, Ru[(bpy)2(pedppz)]2+ (1) and Ru[(bpy)2(pemitatp)]2+ (2) (bpy = 2′2-bipyridine, pdeppz = 10-(2-(piperidin-1-yl)ethoxy)dipyrido[3,2-a:2′,3′-c]phenazine, pemitatp = 5-methoxy-1-(2-(piperidin-1-yl)ethyl)-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene), bearing large planar π-delocalized aromatic systems with flexible chains have been synthesised and characterised. As expected, these complexes show inhibition towards telomerase by inducing and stabilising the G-quadruplex structure.

Graphical abstract: Novel ruthenium(ii) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors

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Publication details

The article was received on 18 Dec 2013, accepted on 08 Mar 2014 and first published on 10 Mar 2014


Article type: Paper
DOI: 10.1039/C3DT53547A
Citation: Dalton Trans., 2014,43, 7811-7819
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    Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors

    G. Liao, X. Chen, J. Wu, C. Qian, H. Wang, L. Ji and H. Chao, Dalton Trans., 2014, 43, 7811
    DOI: 10.1039/C3DT53547A

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