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Issue 13, 2014
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Mesoporous silica nanoparticles for enhancing the delivery efficiency of immunostimulatory DNA drugs

Cuilian Tao,a  Yufang Zhu,*b  Yi Xu,a  Min Zhu,b  Hiromi Moritac  and  Nobutaka Hanagatac 
Author affiliations

* Corresponding authors

a School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai, China

b School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai, China
E-mail: zjf2412@163.com
Tel: +86-21-55271663

c Nanotechnology Innovation Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Japan

Abstract

We developed a potential immunostimulatory double-stranded DNA (dsDNA) delivery system by the binding of dsDNA to amino-modified mesoporous silica nanoparticles (MSNs) to form MSN-NH2/dsDNA complexes. Serum stability, in vitro cytotoxicity, cell uptake, and type I interferon-α (IFN-α) induction of MSN-NH2/dsDNA complexes were evaluated. The results showed that MSN-NH2 nanoparticles had no cytotoxicity to Raw 264.7 cells, and MSN-NH2/dsDNA complexes enhanced the serum stability of dsDNA due to the protection by nanoparticles and exhibited a high efficiency of cell uptake due to a small particle size and excellent dispersity. Most importantly, MSN-NH2/dsDNA complexes significantly enhanced the level of IFN-α induction, triggered by cytosolic DNA sensor proteins. Therefore, binding of immunostimulatory DNA to MSNs would play a promising role for enhancing the delivery efficiency of immunostimulatory DNA drugs.

Graphical abstract: Mesoporous silica nanoparticles for enhancing the delivery efficiency of immunostimulatory DNA drugs

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Publication details

The article was received on 06 Dec 2013, accepted on 13 Jan 2014 and first published on 14 Jan 2014


Article type: Paper
DOI: 10.1039/C3DT53433B
Author version available: Download Author version (PDF)
Citation: Dalton Trans., 2014,43, 5142-5150
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    Mesoporous silica nanoparticles for enhancing the delivery efficiency of immunostimulatory DNA drugs

    C. Tao, Y. Zhu, Y. Xu, M. Zhu, H. Morita and N. Hanagata, Dalton Trans., 2014, 43, 5142
    DOI: 10.1039/C3DT53433B

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