A copper complex supported by an N2S-tridentate ligand inducing efficient heterolytic O–O bond cleavage of alkylhydroperoxide

Abstract

We have recently reported a copper(II)-superoxide complex supported by an N₃-tridentate ligand (L^N3), which exhibits a similar structure and reactivity to those of a putative reactive intermediate involved in the catalytic reactions of copper monooxygenases such as peptidylglycine α-hydroxylating monooxygenase (PHM) and dopamine β-monooxygenase (DβM). In this study, we have synthesised and characterised copper complexes supported by a related sulphur-containing ligand (L^N2S) to get insight into the notable electronic effect of the sulphur donor atom in the reaction with cumene hydroperoxide, inducing efficient heterolytic O–O bond cleavage.