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Issue 10, 2014
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Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

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Abstract

A series of ruthenium(II) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL−1) and minimum bactericidal concentration (MBC, 25 μg mL−1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL−1 and MBC = 100 μg mL−1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL−1, MBC, >100 μg mL−1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Graphical abstract: Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

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Publication details

The article was received on 13 Oct 2013, accepted on 14 Dec 2013 and first published on 16 Dec 2013


Article type: Paper
DOI: 10.1039/C3DT52879K
Citation: Dalton Trans., 2014,43, 3949-3957
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    Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

    P.-L. Lam, G.-L. Lu, K.-M. Hon, K.-W. Lee, C.-L. Ho, X. Wang, J. C.-O. Tang, K.-H. Lam, R. S.-M. Wong, S. H.-L. Kok, Z.-X. Bian, H. Li, K. K.-H. Lee, R. Gambari, C.-H. Chui and W.-Y. Wong, Dalton Trans., 2014, 43, 3949
    DOI: 10.1039/C3DT52879K

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