Synthesis and characterization of a novel o-tolyltelluronic trimethyltin ester and its cytotoxic assessment in vitro

Abstract

A new arenetelluronic triorganotin ester, namely (Me₃Sn)₄[o-Me-PhTe(μ-O)(OH)O₂)]₂ (1) has been prepared by the reaction of o-tolyltelluronic acid and Me₃SnCl in the presence of potassium hydroxide. The complex was fully characterized by elemental analysis, FT-IR, NMR (¹H, ¹³C, ¹¹⁹Sn) spectroscopy and X-ray crystallography. Structure analysis revealed that the complex crystallized as Sn₄Te₂ units and a 1D linear chain was formed by intermolecular C–H⋯O interactions. Cytotoxic assessments showed that the complex can induce apoptotic cell death via accumulation of ROS, collapse of the MMP and activating caspase-3. The results indicated that ROS is crucial to the cytotoxicity induced by the complex.