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Issue 7, 2014
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Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols

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Abstract

Chiral nucleophilic catalysts, 6-aryl-phenyl-dihydroimidazoquinolines (PIQs), were designed, synthesised and applied to the kinetic resolution of arylalkyl carbinols with very high selectivity (S) factors (up to 530). Density functional theory calculations indicate that multiple noncovalent interactions play a key role in chiral recognition between 6-aryl-PIQ catalysts and chiral secondary alcohol substrates.

Graphical abstract: Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols

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Publication details

The article was received on 08 Nov 2013, accepted on 03 Dec 2013 and first published on 03 Dec 2013


Article type: Communication
DOI: 10.1039/C3CY00904A
Citation: Catal. Sci. Technol., 2014,4, 1909-1913
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    Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols

    Z. Wang, J. Ye, R. Wu, Y. Liu, J. S. Fossey, J. Cheng and W. Deng, Catal. Sci. Technol., 2014, 4, 1909
    DOI: 10.1039/C3CY00904A

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